Mannich reaction of 1,4-dihydroquinoline derivatives.
نویسندگان
چکیده
منابع مشابه
The Redox-Mannich Reaction
A complement to the classic three-component Mannich reaction, the redox-Mannich reaction, utilizes the same starting materials but incorporates an isomerization step that enables the facile preparation of ring-substituted β-amino ketones. Reactions occur under relatively mild conditions and are facilitated by benzoic acid.
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A new chemoselective reductive nitro-Mannich cyclization reaction sequence of nitroalkyl-tethered lactams has been developed. Relying on the rapid and chemoselective iridium(I)-catalyzed reduction of lactams to the corresponding enamine, subsequent nitro-Mannich cyclization of tethered nitroalkyl functionality provides direct access to important alkaloid natural-product-like structures in yield...
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2-Aminoquinolin-4(1H)-one was reacted with various primary/secondary amines and paraformaldehyde under Mannich reaction conditions. In the case of secondary amines, the reaction in N,N-dimethylformamide yielded expected Mannich products accompanied with 3,3'-methylenebis(2-aminoquinolin-4(1H)-one). Except these main products, the pyrimido[4,5-b]quinolin-5-one derivative was also identified as c...
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A series of new mannich base derivatives 4-(furan-2-yl(2-(furan-2-yl methylene)hydrazinyl)methyl)morpholine(1-6) were synthesized and synthesized compounds (16) were confirmed by IR, 1H NMR, 13C NMR, Mass spectral, mass spectral fragmentation and elemental analysis. Synthesized compounds (1-6) were screened for antimicrobial activity. Structural activity relationship has been discussed in this ...
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A highly diastereo- and enantioselective Mannich-type reaction of 3-aryloxindoles with N-Boc aldimines was achieved under the catalysis of axially chiral ammonium betaines. This catalytic method provides a new tool for the construction of consecutive quaternary and tertiary stereogenic carbon centers on biologically intriguing molecular frameworks with high fidelity.
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1981
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.29.3712